Table 2 Thematic analysis yielded 3 overarching themes and relevant sub-themes

Theme 1: Reason to support return of individual multi-omics result

• Participant Rights to Their Own Data

• Perception of Minimal Harms

• Future Value of Multi-omics Information

Theme 2: Concerns about return of multi-omics research result

• Complex Interpretation with Uncertain Clinical Validity

• Lack of Clear Obligations to Return Multi-omics Results

• Expertise Required to Communicate Multi-omics Result

Theme 3: Need for external guidance from funding agencies