Fig. 3

Health status eligibility criteria and data collection. Abbreviations: Spec = specified. Not spec = not specified. ECOG = Eastern Cooperative Oncology Group; WHO = World Health Organisation A) Pregnancy status eligibility. Pregnancy status N = 21, 9 trials excluded as they had only male sex participants. E) Brain metastasis N = 17, 13 trials excluded as they were in early-stage non-metastatic cancer, so all metastases were excluded